Most of us would hardly have heard of the Zika virus disease or Zika, as it is commonly known. The Zika is a disease caused by the Zika virus that is spread to the people, primarily through the bite of an infected Aedes species mosquito. The most common symptoms of the Zika virus disease are fever, rash, joint pain, and conjunctivitis. The illness is usually mild, and the symptoms last for several days to a week.
The illness caused as a result of the Zika virus is quite mild, and many people do not even realize that they have been infected with the virus.
The most common symptoms of the Zika virus disease are fever, rash, joint pain, or conjunctivitis. The symptoms, usually, begin 2 to 7 days after being bitten by an infected mosquito.
The Zika virus is transmitted through the bite of infected Aedes mosquitoes. Most of you would remember that it is the same mosquito that spreads Chikungunya and dengue. These mosquitoes are predominantly aggressive daytime biters, but they can also bite at night. Mosquitoes become infected when they bite a person already infected with the virus. Infected mosquitoes then spread the virus to other healthy people through bites. Infected mosquitoes can also transmit the virus from a pregnant mother to her baby during pregnancy.
There are no commercially available diagnostic tests for the Zika virus disease. Healthcare providers are encouraged to report suspected Zika cases to their state or local health department to facilitate diagnosis and mitigate the risk of local transmission.
See your doctor or your personal physician if you develop symptoms such as fever, rash, joint pain, and red eyes. If you have recently traveled to any country that has prevalence of Zika, discuss with your doctor for further management.
During the first week after onset of symptoms, the Zika virus disease can be diagnosed by performing Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) on serum. Virus-specific IgM and neutralizing antibodies typically develop toward the end of the first week of illness. Cross-reaction with related flaviviruses (such as dengue and yellow fever viruses) is common and may be difficult to differentiate.
Plaque-reduction neutralization testing can be done to measure virus-specific neutralizing antibodies and discriminate between cross-reacting antibodies in primary Flavivirus infections. Test results are normally available between 4 to 14 days after the receipt of the specimen. The test results can take longer during summer months when the Arbovirus activity increases.
Biological confirmation of ZIKV infections is based mostly on the detection of virus RNA in serum by using reverse transcription PCR (RT-PCR). Although IgM against ZIKV can be detected by ELISA, only a few laboratories have this ability. Thus, in addition to the nonspecific clinical features of infection with ZIKV, laboratory diagnosis is challenging because of low viremia and cross-reactivity of ZIKV antibodies with other Flaviviruses. The diagnosis requires confirmation by neutralization assays and makes rapid serologic confirmation difficult. The diagnostic utility of urine as a source for detection of ZIKV RNA by real-time RT-PCR is also investigated.
Infants should be tested for the Zika virus either if their mothers had a positive or inconclusive test for the virus, or if they were born with microcephaly or intracranial calcifications, and their mothers had resided in or traveled to an area with Zika virus transmission.
The first thing to do for any potentially infected infant is to test the mother, and then the infant for the Zika virus. It should be remembered that even if the infant tests negative, an ophthalmologic evaluation within the first month of life, and a repeat hearing test at 6 months should be done. This should be done as abnormal eye findings and delayed hearing loss has been present in infants potentially infected with the virus.
If the test is positive or inconclusive, but the infant does not present with microcephaly or intracranial calcifications, a comprehensive physical examination, including evaluation for neurologic abnormalities should be done. This should also include full body photographs to check for dysmorphic abnormalities. The infant should also have a cranial ultrasound, unless a prenatal ultrasound showed no brain abnormalities in the third trimester.
Microcephaly is a condition where the circumference of the head is smaller than normal. Microcephaly may be caused by genetic abnormalities or by drugs, alcohol, certain viruses, and toxins that are exposed to the fetus during pregnancy and damage the developing brain. Microcephaly could also be caused by the Zika virus.
Zika virus RT-PCR and serology assays can be performed on maternal serum or plasma. Zika virus RT-PCR can also be performed on amniotic fluid.
Other testing that can performed includes the following:
So far, there is no known vaccine to prevent Zika. The best way to prevent the disease is to avoid being bitten.
Protect yourself and your family from mosquito bites by:
Ensure that you sleep under a mosquito net at all times if you are outside and are not able to protect yourself from mosquito bites.
There is no vaccine or specific medicine to treat Zika virus infections.
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